The study shows that chemical coatings can affect the “swimming” of fine particles in mucous solutions

a ) avidin-coated magnetic microparticles are activated with one of three compounds: biotin, biotin-PEG3-amine, or biotin-chitosan. The functionalized microparticles are suspended in a 4% mucin solution and loaded into a sample chamber which is placed in the middle of an approximate Helmholtz coil system. Programmable power supplies and camera imaging are used to move microparticles through mucus using rotating magnetic fields. Chemical structures were extracted from Chemspyder and HAworks. ( b ) magnetic fields produced from the Helmholtz coil system and their relationship to Eqs. (1-3). When rotated by a magnetic field, tiny particles in a climbing rod-like fluid will propel along the thrust axis perpendicular to their plane of symmetry. Two payment states can be achieved ( u + , u ) randomly when a fixed field is not applied (< i> B s = 0). Any of the push states can be specified as desired when applying a non-zero constant field ( B s ≠ 0). The red and blue hemispheres represent magnetic dipoles. Credit: Scientific Reports (2022). DOI: 10.1038 / s41598-022-21725-z” width=”800″ height=”530″/>

Overview of the experimental setup and magnetic field interactions. (a) magnetic microparticles coated with avidin are activated with one of three compounds: biotin, biotin-PEG3-amine, or biotin-chitosan. The functionalized microparticles are suspended in a 4% mucin solution and loaded into a sample chamber which is placed in the middle of an approximate Helmholtz coil system. Programmable power supplies and camera imaging are used to move microparticles through mucus using rotating magnetic fields. Chemical structures were extracted from Chemspyder and HAworks. (B) magnetic fields produced from the Helmholtz coil system and their relationship to Eqs. (1-3). When rotated by a magnetic field, tiny particles in a climbing rod-like fluid will propel along the thrust axis perpendicular to their plane of symmetry. Two payment states can be achieved (Yu+And theYu) randomly when no fixed field is applied (Bs = 0). Any of the push states can be specified as desired when applying a non-zero constant field (Bs ≠ 0). The red and blue hemispheres represent magnetic dipoles. attributed to him: Scientific reports (2022). DOI: 10.1038/s41598-022-21725-z

Collaborative research between SMU’s Biological Actuation, Sensing, and Transportation (BAST) Laboratory at SMU, Sensing and Transportation (BAST) and international research and engineering firm ARA has shown, for the first time, that certain chemical coatings, applied to micro/nanoparticles, can alter their propulsion. in swimming within biological material. liquids.

The joint research is published in Scientific reports.

The study concluded that designing specialized surface coatings to generate specific propellant properties will provide new avenues for drug delivery strategies. The ability to navigate microparticles at speed will support the deployment of drugs when speed of delivery is critical to patient recovery. In addition, the ability to precisely navigate these tiny “swimming” particles would allow them to travel through complex fluid and tissue environments to target locations in the human body.

“Thanks to the SMU partnership, we will continue to push the boundaries of microrobotics research and look forward to sharing our continued work with the scientific community,” said Louis William Rogowski, ARA’s Senior Investigator in Microrobotics. We are honored to publish our joint research in Scientific reports. ”

Rogowski, Kim, and their team members were able to demonstrate that altering the surface chemistry of microparticles can dynamically alter propulsion behavior.

“We are excited to see the feasibility of chemically encapsulated magnetic microparticles for precise navigation in elastic body environments,” said Kim, the Robert C. Womack chair in SMU’s Lyle College of Engineering and principal investigator in the BAST lab. “We will continue to work together to develop a new type of micro-robot for targeted drug delivery systems.”

In this study, biotin, Biotin-PEG3-amine and biotin chitosan were chemically applied to the surface of microparticles. The coated microparticles were then suspended in mucus synthesized from porcine gastric mucus (glycoproteins found in mucus) and navigated using rotating magnetic fields using a spontaneous symmetry-breaking push mechanism. Surface coatings altered the propelling behavior of the microparticles, depending on both magnetic field properties and localized mucus properties.

The researchers say the next steps include coating the microparticles with an actual pharmaceutical compound and measuring uptake within living environments using “swarms” of microparticles, or examining the interactions of cellular membranes. Designing specialized surface coatings to generate specific propellant properties will also provide new avenues for drug delivery strategies. The authors hope that the study will increase interest in microparticle-based propulsion mechanisms and help provide novel innovations for targeted drug delivery applications.

more information:
Louis William Rogowski et al., Spontaneous symmetry breaking propulsion of chemically encapsulated micromagnetic particles, Scientific reports (2022). DOI: 10.1038/s41598-022-21725-z

Provided by Southern Methodist University

the quote: Study Shows Chemical Coatings Can Affect Fine Particles ‘Swimming’ in Mucous Solutions (2022, November 22), Retrieved November 22, 2022 from https://phys.org/news/2022-11-chemical-coatings -affect-microparticles-mucus.html

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